Ozone therapy as complementary therapy type

According to the Low-Dose-Principle

The healing properties of ozone have recently become an indisputable fact among experts. Alternative therapists and non-medical practitioners make use of the positive, biological properties of ozone within the scope of the so-called ozone therapy to accelerate the wound healing of patients and to revitalise their immune system.

The major autohemotherapy as an extracorporeal blood treatment with micro-pearl system and germ stop in the hygiene set is recommended by the Medical Society for Ozone Application in Prevention and Therapy as one of the basic systemic application forms of medical ozone. You can find further information here: Ärztliche Gesellschaft für Ozonanwendung in Prävention und Therapie / Medical Society for the use of ozone in prevention and therapy (ozongesellschaft.de)

How is ozone generated?

Nitrogen dioxide (NO2) is considered to be the most important precursor for ozone generation and decomposes to nitrogen monoxide (NO) and atomic oxygen (O) by the action of UV light. The formed oxygen radicals are highly reactive and combine with other oxygen molecules or air-oxygen (O2) to ozone (O3).

Sauerstoffatome verbinden sich mit Sauerstoffmolekül zu Ozonmolekülen

Unlike the diatomic air-oxygen (O2) needed for breathing, the ozone molecule (O3) consists of three oxygen atoms.

What does Ozone Therapy mean?

Ozone therapy – a definition

The ozone therapy also referred to ozone/oxygen therapy is considered to be an alternative treatment method using medical ozone (O3). For the ozone therapy, medical doctors and non-medical practitioners make use of the antiseptic and disinfecting effect of ozone, for instance to cure wounds. Furthermore, ozone can be used to simulate the immune system or to treat circulatory disturbances.

Medical ozone and its effects

Medical ozone is produced by means of a so-called ozone generator. For therapeutic purposes, due to its metastable property, ozone needs to be produced at the place of consumption itself.

Ozongenerator alphaplus
ozongenerator alphalpus

Medical ozone consists of 0.05 to 5% of purest ozone and 99.95 to 95% medical pure oxygen (AMG). Ozone acts toxic from concentration of approximately 50 to 60 µg/ml onwards. Even lower concentrations must by no means be inhaled as it is susceptible to damage the respiratory system.

Excursus – History of Ozone Therapy

Ozone has already been applied in medicine for about 100 years: In 1857, Werner von Siemens developed the first technical ozone equipment – an ozone tube. At the beginning of the 1920s, the first insufflations (gas injection) have been performed by means of an ozone generator applied for medical purposes.

In the 1950s, Dr. Joachim Hänsler, born in Silesia and deceased in 1981, laid the foundation for our modern ozone therapy with his medical ozone generator. Jointly with Hans Wolff, he developed the bases and founded the “Medical Association for Ozone Therapy”, which eventually was renamed to “Medical Association for Ozone Application for prevention and therapy”.

What kind of dosage forms are available in terms of ozone therapy?

For medical ozone therapy we distinguish between systemic and topic applications when it comes to the manner by which ozone is administered to patients.

Systemic applications methods

Major Ozone Autologous Blood Infusion / Major Autohaemotherapy

For major autohaemotherapy, first approximately 50 to 100 ml of blood are taken from the patient’s arm vein, the blood sample directly being transferred into a disposable dropper bottle. The blood sample is enriched with an ozone/oxygen mixture and subsequently re-injected as pressure-free infusion.

Minor autohaemotherapy

For minor autohaemotherapy, approximately 1 to 3 and 5 ml are taken from the vein, then being combined with an ozone/oxygen mixture and re-injected by means of ozone-resistant, siliconised disposable syringes to the gluteal muscle or under the skin as intramuscular injection.

Ozontherapie Intraartikuläre Ozoninjektion

Rectal Insufflation (RI)

As a very good alternative to major autohaemotherapy, rectal ozone insufflation can be applied. For this treatment, the ozone/oxygen mixture is introduced through the patient rectum into the intestine by means of a bag.

Topic application methods

Transcutaneous gas bath

In colloquial language, it is also referred to as “bag gassing”. For the transcutaneous gas bath, the affected body part, showing for instance eczemas or open wounds, is covered with an ozone-resistant plastic bag. Subsequently, ozone is blown into the bag. Inside the bag, medical ozone kills bacteria, viruses and fungi available on the damp skin.

Action mode of the transcutaneous gas bath

  • wound cleansing
  • bactericidal
  • fungicidal
  • virus deactivating

Ozonized Water

Ozonized water is suitable for topic (thus external) applications. In the first stage, ozone/water compresses may relieve the pain of an inflammation, during oedema formation, and may cause the oedema to rapidly recede.

Also for dentistry purposes ozonized water is widely used. It acts as disinfectant when rinsing the oral cavity or during jaw surgeries and is able to even reach infection sources that are difficult to access.

Direct Injection Therapy

For injection therapy 10 to 20 ml of medical ozone are in most cases administered subcutaneously (under the skin), intravenously (into the vein) or intramuscularly (into the muscle).

What does ozone therapy cost?

Unfortunately, for ozone therapy there is no general price list available. Prices may vary according to treatment method and duration. As a guideline: Major autohaemotherapy starts at approximately 75 Euro per session. However, the price may be significantly higher if it is combined with additional services, such as vitamin infusions.

In general, patients must bear the costs of the ozone therapy themselves, as statutory health insurances do not cover the expenses. It is thus advisable to gather information on the cost of ozone therapy well in advance. Your direct contacts should be medical doctors and non-medical practitioners.

Contraindications of medical ozone

For certain previous diseases or under special circumstances, ozone therapy should not be applied, as secondary effects must be expected.

For example, in case of leukaemia or within the first three months of pregnancy, all kinds of ozone therapy are discouraged.

Overview of common contraindications

  • patients under 18 years age
  • acute haemolytic anaemia
  • haemophilia
  • favism
  • uncontrolled hyperthyreosis (thyroid overactivity)
  • pregnant or breastfeeding women
  • leukaemia

Successfully treated with the low-dosage-principle

Ozone therapy should always be applied complementary and in addition to other basic therapies, in order to achieve the best medical success. The effect of ozone significantly depends on the ozone concentration and the ozone dosage. The hormesis principle is of major importance for ozone therapy.
In the low doses section, thus within a range of 10 and 40 µg ozone/ml, medical ozone is highly effective for systemic purposes.
For topic use, hence for external applications, ozone concentration from 60 to 100 µg/ml are recommended to cure infected wounds.

With increasing concentration the therapeutic effect will decrease. From a certain level upwards ozone is toxic. Successful ozone therapy thus depends on the correct concentration and dosage of well-adapted applications.


More Publications

What actually is ozone? Which are its indications and contraindications? How does an ozone therapy act and which kinds of ozone therapy are available? All of these questions and many more will be answered in our Ozonosan Magazine. For decades we have conducted research in the field of ozone therapy and have continuously enhanced our products. Here, both medical personnel and patients will find useful information on the subject of ozone therapy. Please come back and visit our site regularly as it is continuously updated.