Material Requirements for Ozone Therapy

The success of the ozone therapy decisively depends on the used materials and the applied ozone generator.

Since ozone is highly reactive, the used materials must be selected with utmost care in order to prevent undesirable side-effects (material dissolution due to decomposition and the creation of toxic substances). This starts already with choosing the starting substance – oxygen.

Medical oxygen

In contrast to technical ozone generators, for medical application only medical oxygen in the form of generator gas may be applied, in order to ensure a high quality of the ozone/oxygen mixture. Neither air nor oxygen concentrators must be applied for this purpose, since the necessarily added nitrogen will lead to the creation of nitrogen oxides in the discharge area (dielectrically limited discharge).

Quality assurance and quality control

Quality assurance and quality control require that materials are selected with care, in the first place in terms of the ozone generator itself, and secondly also in terms of the consumables that come into contact with ozone, such as sterile disposables used for therapy.

  • For medical ozone generators solely special materials may be applied: Teflon (PTFE), hard-anodized (hard-coated) aluminium, V4A steels, glass and ceramics.
    Also for ozone applications only entirely ozone-resistant materials such as glass, polyethylene (PE), polypropylene (PP) and Teflon PTFE must be applied.
  • Other plastic materials, especially rubber at the syringe piston, have to be siliconised for ozone therapy and need to be checked as to their ozone-resistance.
  • For the infusion of ozonized autologous blood (major autohaemotherapy) only glass containers may be used. Plasma or blood bags, consisting of PVC, are not ozone-resistant, so that xenobiotic and toxic substances could be dissolved. Latex-free materials must be used in order to prevent latex allergies by all means.
  • Ozonized water as well is highly reactive. This is why only glass containers are suitable for the production and storage of ozonized water.

Concentration measurement

Unlike other pharmaceuticals, ozone needs to be produced at the site of consumption as the ozone molecule only has a limited stability. For applications decay times or half-lives need be considered.

Ozone concentrations and decay are extremely dependent on parameters such as temperature, pressure, gas flow (volume flow) among others. Continuous concentration measurement is thus indispensable. For this purpose, medical ozone generators must always be provided with a concentration measurement unit in order to sustainably ensure the quality of the ozone/oxygen mixture.


More Publications

What actually is ozone? Which are its indications and contraindications? How does an ozone therapy act and which kinds of ozone therapy are available? All of these questions and many more will be answered in our Ozonosan Magazine. For decades we have conducted research in the field of ozone therapy and have continuously enhanced our products. Here, both medical personnel and patients will find useful information on the subject of ozone therapy. Please come back and visit our site regularly as it is continuously updated.